ChemInform Abstract: Total Synthesis and Bioactivity of the Marine Alkaloid Pityriacitrin and Some of Its Derivatives.

Abstract

Total Synthesis and Bioactivity of the Marine Alkaloid Pityriacitrin and Some of Its Derivatives. -A novel access to pityriacitrin (IIIa) and several of its analogues via modified Pictet-Spengler reaction is described. Biological studies reveal that (IIIa) has a weak antiproliferative activity against a panel of breast and prostate cancer cell lines, whereas some of the derivatives exhibit stronger activity, which is associated with induction of both cell apoptosis and necrosis. -(ZHANG, P.; SUN, X.; XU, B.; BIJIAN, K.; WAN, S.; LI, G.; ALAOUI-JAMALI, M.; JIANG*, T.; Eur. J. Med. Chem. 46 (2011) 12, 6089-6097, http://dx.