ChemInform Abstract: TiCl₄/tert‐Butyl Hydroperoxide: Chemioselective Oxidation of Secondary Alcohols and Suppression of Sharpless Epoxidation.

Abstract

Oxidation O 0212TiCl4/tert-Butyl Hydroperoxide: Chemioselective Oxidation of Secondary Alcohols and Suppression of Sharpless Epoxidation. -In the presence of TBHP and catalytic amounts of TiCl4, secondary alcohols undergo chemoselective oxidation to ketones. Primary alcohols and C=C double bonds are not attacked. The 1,3-diol (IIIb) yields exclusively the hydroxyl ketone (IVb) and starting from 1,2-diols no ketones are obtained.