ChemInform Abstract: The β‐Lactam‐Nucleoside Chimera.

Abstract

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Design, Synthesis, and Antiviral Evaluation of Purine-β-lactam and Purine-aminopropanol Hybrids

“…1 H NMR spectra were recorded at 300 MHz (JEOL ECLIPSE+) with CDCl 3 as solvent and tetramethylsilane as internal standard. 13 C NMR spectra were recorded at 75 MHz (JEOL ECLIPSE+) with CDCl 3 as solvent and tetramethylsilane as internal standard. Mass spectra were obtained with a mass spectrometer Agilent 1100, 70 eV.…”

“…The concept of nucleoside-β-lactam chimera as potentially bioactive systems has been introduced in 1995, although only three pyrimidine-β-lactam hybrids were prepared and their bioactivity was not assessed. 13 These systems were synthesized through the Ugi reaction using a β-amino acid, an aldehyde, and an isocyanide. More recently, an alternative approach toward similar combinations of β-lactams and nucleobases (both purine-and pyrimidine-based) has been described based on the Kinugasa reaction starting from Npropargyl nucleobases.…”

“…The study of new hybrid systems in which purines and β-lactams are combined comprises an unexplored field of research. The concept of nucleoside-β-lactam chimera as potentially bioactive systems has been introduced in 1995, although only three pyrimidine-β-lactam hybrids were prepared and their bioactivity was not assessed . These systems were synthesized through the Ugi reaction using a β-amino acid, an aldehyde, and an isocyanide.…”