ChemInform Abstract: The Total Synthesis of Roquefortine C and a Rationale for the Thermodynamic Stability of Isoroquefortine C over Roquefortine C.

Abstract

Alkaloids U 0600The Total Synthesis of Roquefortine C and a Rationale for the Thermodynamic Stability of Isoroquefortine C over Roquefortine C. -Molecular modeling studies explain the instability of the (E)-configurated title compound (Ia) compared to that of the unnatural isoroquefortine C (Ib). -(SHANGGUAN, N.; HEHRE, W. J.; OHLINGER, W. S.; BEAVERS, M. P.; JOULLIE*, M. M.; J.