ChemInform Abstract: The Synthesis and Biological Activity of a Highly Selective Adenosine A_2a Receptor Agonist.

Abstract

The Synthesis and Biological Activity of a Highly Selective Adenosine A 2a Receptor Agonist.-Compound (III) is shown to be the most selective A 2a receptor agonist reported to date having an A 1 /A 2 ratio of 2400. In addition, (III) reduces blood pressure in rats and dogs with only minimal effects on heart rate. -(BORCHERDING, DAVID R.; LENTZ, NELSEN L.; WEINTRAUB, PHILIP M.; DUDLEY, MARK W.; SECREST, ROBERTA; KASTNER, PHILIP R.; PEET, NORTON P.; Nucleosides Nucleotides 18 (1999) 10, 2175-2191; Hoechst Marion Russel, Inc., Bridgewater, NJ 08807, USA; EN)