ChemInform Abstract: The Enantioselective Construction of Tetracyclic Diterpene Skeletons with Friedel—Crafts Alkylation and Palladium‐Catalyzed Cycloalkenylation Reactions.

Abstract

Reactions. -Tricarbocyclic products (II) are obtained by an extension of the enantioselective Birch-Cope sequence with Friedel-Crafts alkylation reactions. Furthermore, the bicyclo[3.2.1]octanes are constructed by palladium-catalyzed enol silane cycloalkenylation of the tricyclic structures. -(BURKE, S. J.; MALACHOWSKI*, W. P.; MEHTA, S. K.; APPENTENG, R.; Org. Biomol. Chem. 13 (2015) 9, 2726-2744, http://dx.doi.org/10.1039/C4OB02489C ; Dep. Chem., Bryn Mawr Coll., Bryn Mawr, PA 19010, USA; Eng.) -H. Toeppel