ChemInform Abstract: The Chemistry of Vicinal Tricarbonyl Compounds. Applications in the Synthesis of Isoquinoline Alkaloids.

Abstract

Coupling of the benzoyl chlorides (I) with the tert‐butoxycarbonylmethylenephosphorane (II), followed by ozonolysis, produces the α,β‐diketo esters (IV).

Discrimination between amino acid amide conformers by imprinted polymers

“…When substituted on /Mactam rings, they have served as acceptor centers for the construction of the fused 4,5-bicyclic systems of carbapenams and penems.1 In combination with neighboring ester or vinyl groups, they have taken part in cyclization reactions leading to vincamine,2 erythrina,3 and phthalideisoquinoline alkaloids. 4 Other applications have been reported in the synthesis of hy-droxypyrroles5 including the bacterial pigment, prodigiosin.6…”