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ChemInform Abstract: Tetrahydropyridine Derivatives with Inhibitory Activity on the Production of Proinflammatory Cytokines. Part 2.
Abstract: Part 2. -The synthesis and biological activity of Nand α-position substituted tetrahydropyridine derivatives is presented. It is found that compound (IIIf) exhibits good inhibitory activity in the LPS-induced TNFα production in human whole blood compound (IV) has the most potent inhibitory activity in mice. -(NAKAO*, A.; OHKAWA, N.; NAGASAKI, T.; KAGARI, T.; DOI, H.; SHIMOZATO, T.; USHIYAMA, S.; AOKI, K.; Bioorg. Med. Chem. Lett
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