ChemInform Abstract: Terpenoids Produced by Actinomycetes: Isolation, Structural Elucidation and Biosynthesis of New Diterpenes, Gifhornenolones A and B from Verrucosispora gifhornensis YM28‐088.

Abstract

Terpenoids Produced by Actinomycetes: Isolation, Structural Elucidation and Biosynthesis of New Diterpenes, Gifhornenolones A and B from Verrucosispora gifhornensis YM28-088. -Labeling experiments confirm that the MEP (2-C-methyl-D-erythritol-4-phosphate) pathway is used for the biosynthesis of gifhornenolone A (I) and B (II) in the title microorganism. Because of its structural similarity to steroidal compounds (I) shows potent androgen antagonist activity. -(SHIRAI, M.; OKUDA, M.; MOTOHASHI, K.; IMOTO, M.; FURIHATA, K.; MATSUO, Y.; KATSUTA, A.; SHIZURI, Y.; SETO*, H.; J.