ChemInform Abstract: TERPENOIDS‐ PART CXXX ‐ A NEW SYNTHESIS OF DEHYDRO‐α‐CURCUMENE

Mutagenicity of para-substituted α-methylstyrene oxide derivatives with Salmonella

“…Except for a-methylstyrene oxide, which is commercially available, the compounds of interest were synthesized by the methylene insertion method of Corey and Chaykovsky (1965) as modified by Vig et al (1977). The physical-chemical properties for these new compounds are given in Table 1.…”

“…However, it is unlikely that such carbonyl compounds contributed to the mutagenicity of the parent oxiranes of this study as no mutagenicity could be established for 2phenylpropionaldehyde (Aldrich) under our test conditions. Moreover, chromatography on deactivated neutralized alumina (Vig et al, 1977) produced, for most of the a-methyl epoxide derivatives, compounds of high purity as indicated by their spectral characteristics as well as by their homogeneity on the HPLC and TLC systems described in the experimental section. However, in the case of p-phenyl-t~-methylstyrene oxide, chromatography and attempted distillation actually promoted decomposition.…”

“…The other a-methylstyrene oxides in Table 1 were synthesized from their corresponding phenyl methyl ketones (Aldrich) by application of the methylene insertion reaction (Corey and Chaykovsky, 1965;Vig et al, 1977). Except for the paraphenyl compound, purification was possible by chromatography over neutral alumina (150 mesh, grade 1, Aldrich) in which 1 g of the reaction mixtures were applied to a gravity column of 30 g alumina (deactivated to grade III with 1.2 ml H20 ) and CH2C12-hexane (8:2) was the eluting solvent.…”