ChemInform Abstract: Synthetic Methods for the Preparation of Basic D‐ and L‐Pseudo‐Sugars. Synthesis of Carbocyclic Analogues of N‐Acetyl‐muramyl‐L‐alanyl‐D‐isoglutamine (MDP).

Abstract

The carbocyclic analogue (VII) and the carbocyclic nor‐analogue (VIII) of MDP (IX) are prepared in order to modify the immunostimulating activities of this compound.

Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus

“…The synthesis of carba-sugar 8 is depicted in Figure B. Methyl glycoside 10 was converted to carba-cycle 11 as described by Barton et al Basic cleavage of the cyclic carbamate gave diol 12 that could be selectively phosphorylated at the primary OH group to yield 13 . Catalytic hydrogenation gave carba-sugar 8 .…”