ChemInform Abstract: Synthesis, Properties, and X‐Ray Analysis of 4‐Trifluoromethyl‐6‐phenyl‐2‐chloro‐3‐cyanopyridine.

Abstract

ChemInform Abstract The title compound (II), prepared from the pyridone (I) and POCl3 in the presence of DMF, reacts with nucleophiles such as (III), (V), (VII), or (IX) to give the corresponding 2-substituted pyridines (IV), (VI), (VIII), or (X). (IVf) is also obtained from (I) and the phosphorous triamide (XI). (X-ray analysis of (II): space group P21/c, Z = 8).

A facile and single pot strategy for the synthesis of novel naphthyridine derivatives under microwave irradiation conditions using ZnCl2 as catalyst, evaluation of AChE inhibitory activity, and molecular modeling studies

“…In a typical reaction, the 2-amino-3-cyano-4-trifluoromethyl-6-phenylpyridine 2 (Narsaiah et al, 1994;Guttsait et al, 1987) was reacted with acetophenone in DMF at 120-130°C for 18 h and found several products. To improve the selectivity, the same reaction was conducted under microwave irradiation conditions using synthos 3000 microwave reactor at 540 W, 130°C and 15 bar pressure using ZnCl 2 as catalyst and on subsequent workup furnished the desired products 3 in high yields.…”