Abstract:Synthesis of trans-2,6-Disubstituted Cyclohexanones Through Allylic Substitution. -trans-2,6-Disubstituted cyclohexanones (IV) are synthesized with high regioand stereoselectivity by allylic substitution followed by ozonolysis. Both aryl and alkyl groups are successfully installed to the cyclohexane ring. The stereochemistry of the S N2' products is determined to be controlled by the pre-existing chirality on the ring. The present method is highlighted by the synthesis of enantiomerically enriched cyclohexanon… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.