ChemInform Abstract: Synthesis of Thiazole Analogues of the Immunosuppressive Agent (1R,2S,3R)‐2‐Acetyl‐4(5)‐(1,2,3,4‐tetrahydroxybutyl)imidazole.

Abstract

4-tetrahydroxybutyl)imidazole. -Reactions between dimethoxyketals of thiazoles and sugar lactones [cf. (I) + (II)] are the starting steps in the preparation of a series of title compounds such as (V)-(VIII), analogues of THI (IX). Preliminary studies reveal that (V) is as active as (IX), whereas (VII) shows a slightly higher activity. -(JEOFFREYS, GEORGE R.; UNG, ALISON T.; PYNE, STEPHEN G.; SKELTON, BRIAN W.; WHITE, ALLAN H.; J.