ChemInform Abstract: Synthesis of the New Ring System 6,8‐Dihydro‐5H‐pyrrolo[3,4‐h]quinazoline.

Abstract

Fused pyrimidine derivatives R 0515 Synthesis of the New Ring System 6,8-Dihydro-5H-pyrrolo[3,4-h]quinazoline. -An interesting method is developed for the synthesis of N-unsubstituted and N-substituted target compounds. Derivative (VIc) exhibits significant antiproliferative activity against various cancer cell lines. -(BARRAJA, P.; SPANO, V.; DIANA, P.; CARBONE, A.; CIRRINCIONE*, G.; Tetrahedron Lett. 50 (2009) 38, 5389-5391; Dip. Farmacochim.-Tossicol. Biol., Univ. Stud., I-90123 Palermo, Italy; Eng.) -Mais 52-172