ChemInform Abstract: Synthesis of Some Novel Pyrazoline and Cyanopyridine Derivatives as Antimicrobial Agents.

Abstract

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Antimicrobial, Antioxidant, and Anticancer Activities of Some Novel Isoxazole Ring Containing Chalcone and Dihydropyrazole Derivatives

“…Replacement of the methoxy group (26 and 28) with either F (30) or Cl (31) resulted in a drop in the antioxidant activity, which suggested that electron-donating groups are favored at positions 2 on the phenyl ring. A similar phenomenon was observed in the dihydropyrazole series (32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Compound 43 was found to have an IC 50 of 6 µg/mL and was the most potent in this series.…”

“…The crude precipitate was recrystallized using chloroform to afford chalcones 17-31. The target dihydropyrazoles (32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) were obtained by treating the synthesized chalcones with semicarbazide in a catalytic amount of pyridine and purified using silica gel column chromatography.…”

“…Hence, we decided to screen our compounds for antibacterial, antifungal, antioxidant, and anticancer (prostrate cell line) activities. The target chalcones (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) and pyrazolines (32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) were tested for their antimicrobial activities by serial tube dilution method against two types of bacterial and fungal strains (Tables 1 and 2). The bacterial strains used for the testing, including Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa, whereas the fungal strains employed were Aspergillus niger and Candida tropicalis.…”

Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives

“…Several pyrazoline derivatives possess important biological activities such as anti-inflammatory [2][3][4], antidepressant [5][6], antipyretic [7], antibacterial [8][9][10][11][12][13], antifungal [8,11,14] and antitumoral [15]. Over the years, the structure of pyrazoline [1,16] has received considerable attention.…”

Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

“…Over the years, the chemistry of 1H-pyrazoles has received considerable attention [1,2]. It is worthy of note that substances containing a 1H-pyrazole moiety have been described as having potential therapeutic utility, such as antiinflammatory [3][4][5], antidepressant [6,7], antipyretic [8], antibacterial [9][10][11][12][13][14], antifungal [12,15] and antitumoral [16]. Of particular interest is the use of 1H-pyrazoles as synthetic intermediates for preparing cyclopropane [17][18][19] and pyrazole derivatives [1,[20][21][22][23][24][25][26].…”