ChemInform Abstract: Synthesis of Some Cyanoazasteroids.

Reaction of 7α-bromo-6-nitrocholest-5-enes with hydrazine: Formation of steroidal pyrazolines and molecular docking against SARS-CoV-2 omicron protease

“…The alternative attack of hydrazine at C7 would have resulted β-oriented product. The unusual upfield shift of C6-proton [37] by δ 0.5 ppm is because of the diamagnetic anisotropic effect of -N=N- which shields the C6-proton falling in the area of conical zone. The mechanism for the formation of pyrazolines has been rationalized below:…”