ChemInform Abstract: Synthesis of Pyrazolo(1,5‐a)pyridines and Pyrazolo(1,5‐c)pyrimidines by Reaction of Heterocyclic Amidrazones with 1,3‐Dicarbonyl Compounds.

Koeckritz, P.; Riemer, B.; Michler, A.; Hassoun, A.; Liebscher, Jürgen

doi:10.1002/chin.199514169

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2012

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“…1,2,4-Triazolo[1,5- a ]pyridines constituted an important class of heterocyclic compounds, which are of considerable interest due to their uses as active ingredients in antihypertensive, bronchodilatory, antiinflammatory, analgesic, and positive inotropic agents. − …”

Section: Introductionmentioning

confidence: 99%

Novel 1,2,4-Triazolo[1,5-a]pyridines and Their Fused Ring Systems Attenuate Oxidative Stress and Prolong Lifespan of Caenorhabiditis elegans

2012

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In this paper we report the synthesis of some novel 1,2,4-triazolo[1,5-a]pyridine and azolotriazolopyridine ring systems. The products were screened for various types of activity like antibacterial, antifungal, and antioxidative activity. Compound 13 was found to pose an antioxidative activity. In addition, this compound was found to extend the life span of Caenorhabiditis elegans under standard laboratory conditions and reduces both heat and chemical induced oxidative stress in C. elegans in a dose-dependent manner. Furthermore, treatment of worms with compound 13 was found to significantly attenuate the formation of advanced glycation end products and malondialdehyde in a dose-dependent manner.

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Section: Introductionmentioning

confidence: 99%

Novel 1,2,4-Triazolo[1,5-a]pyridines and Their Fused Ring Systems Attenuate Oxidative Stress and Prolong Lifespan of Caenorhabiditis elegans

2012

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ChemInform Abstract: Synthesis of Pyrazolo(1,5‐a)pyridines and Pyrazolo(1,5‐c)pyrimidines by Reaction of Heterocyclic Amidrazones with 1,3‐Dicarbonyl Compounds.

Abstract: Synthesis of Pyrazolo(1,5-a)pyridines and Pyrazolo(1,5-c)pyrimidines by Reaction of Heterocyclic Amidrazones with 1,3-Dicarbonyl Compounds.--(KOECKRITZ, P.; RIEMER, B.; MICHLER, A.; HASSOUN, A.; LIEBSCHER, J.; J.

Cited by 1 publication

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Novel 1,2,4-Triazolo[1,5-a]pyridines and Their Fused Ring Systems Attenuate Oxidative Stress and Prolong Lifespan of Caenorhabiditis elegans

Novel 1,2,4-Triazolo[1,5-a]pyridines and Their Fused Ring Systems Attenuate Oxidative Stress and Prolong Lifespan of Caenorhabiditis elegans

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