ChemInform Abstract: SYNTHESIS OF PIPEROVATINE

Abstract

p‐Methoxyphenylacetaldehyd (I), dargestellt aus der entsprechenden Säure über das Chlorid, Anilid und Reduktion mit Lithiumalanagsetzt sich mit dem nach Arbusov erhaltenen Phosphonsäurediäthylester (II) zu dem trans, trans‐Diencarbonsäureester (IIIa) um, der mit Salzsäure zur Säure (IIIb) verseift wird, welche mit Thionyl= Ch10l′id das Chlorid (IIIc) liefert.

Synthesis of myrcene by pyrolysis of β-pinene: Analysis of decomposition reactions

“…Therefore, the errors in the estimated values of the enthalpies of vaporization of myrcene, limonene and 1 [7],8 p-menthadiene will be less than 20%.…”

“…The reactor was fed with b-pinene supplied by Geroma do Brasil Indústria e Comércio Ltda., Ponta Grossa, Paraná, Brazil (composition as molar percentage: 97.01% b-pinene, 1.86% apinene, 0.62% myrcene, 0.29% sabinene, 0.08% allo-ocimene, 0.08% i-limonene, 0.03% 1 [7],8 p-menthadiene and 0.03% limonene). This liquid was fed to the reactor at the stated rate using a peristaltic pump (MILAN).…”

“…Under these conditions, side reactions lead to the formation of not only myrcene but also l-limonene and 1 [7],8 p-menthadiene [11], as shown in Scheme 1. The crude pyrolysis product contains, on a molar basis 75-77% myrcene, 9% limonene, 2% 1 [7],8 pmenthadiene and small quantities of coke [13]. The fact that less than 100% of the original b-pinene appears in the reaction products suggests that decomposition might be occurring, but no previous studies have taken decomposition reactions into account.…”

“…Myrcene can be synthesized through the reaction of ethyl acetoacetate with isoprene bromide and geranyl bromide to give b-keto esters that can then be converted into myrcene through a Witting reaction [7], however, the most commonly reported method involves the pyrolysis of b-pinene at temperatures above 773 K [8][9][10][11][12]. Under these conditions, side reactions lead to the formation of not only myrcene but also l-limonene and 1 [7],8 p-menthadiene [11], as shown in Scheme 1.…”

Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer

“…The first synthesis of alnustone starting from 3-phenylpropionyl chloride was performed in 5 steps by Sakakibara et al 4 Then alnustone (1) was synthesized starting from benzaldehyde by Vig et al 5 In subsequent studies, an alternative synthesis for the preparation of alnustone (1) was developed. 6,7 In a previous study,…”