ChemInform Abstract: Synthesis of Phosphorylated Sulfoximines and Sulfinamides and Their Application as Ligands in Asymmetric Metal Catalysis.

Abstract

Synthesis of Phosphorylated Sulfoximines and Sulfinamides and Their Application as Ligands in Asymmetric MetalCatalysis. -Several sulfoximine-and sulfinamide-based phosphorusamides are prepared from inexpensive and easily available educts. Their applications as ligands in allylic substitution reactions and hydrogenation reactions are described. Phosphorous triamide-type ligands (I) derived from (S)-glutamic acid are found to be the most efficient stereoselectors in palladium-catalyzed allylic substitutions, whereas diamidophosphite-type structures such as (II) stemming from (S)-proline are the best ligands in rhodium-catalyzed hydrogenation reactions. -(BENETSKIY, E. B.; BOLM*, C.; Tetrahedron: Asymmetry 22 (2011) 3, 373-378, http://dx.