ChemInform Abstract: Synthesis of Novel Isothiazole and Isothiazolo(4,5‐d)pyrimidine Analogues of the Natural C‐Nucleosides Pyrazofurin and the Formycins.
Abstract:Synthesis of Novel Isothiazole and Isothiazolo(4,pyrimidine Analogues of the Natural C-Nucleosides Pyrazofurin and the Formycins. -The title compounds (I)-(III) are evaluated for their antiviral and antitumor activity. Despite their structural similarities to pyrazofurin and formycin they do not exhibit activity. -(BUFFEL, D. K.; MEERPOEL, L.; TOPPET, S. M.; HOORNAERT, G. J.; Nucleosides Nucleotides 13 (1994) 1-3, 719-736; Dep. Scheikd., Lab. Org. Synth., Kathol. Univ. Leuven, B-3001 Heverlee-Leuven, Belg.; EN) Show more
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