ChemInform Abstract: SYNTHESIS OF NEW 2‐BENZYLIDENETHIAZOLO(3,2‐A)BENZIMIDAZOL‐3(2H)‐ONES AND THEIR BIOLOGICAL ACTIVITY

Abstract

Das Thiazolobenzimidazolon (I) wird mit den Aldehyden (II) zu den Benzyliden‐Derivaten (III) kondensiert, die antikonvulsive Wirkung besitzen und in vitro Hemmstoffe der Monoamin‐Oxidase und der Succinatdehydrogenase sind.

1H and 13C NMR spectral characterization of some novel 7H‐1,2,4‐triazolo[3, 4‐b] [1,3,4] thiadiazine derivatives

“…1 -3 Broad biological and pharmacological properties of various thiadiazines fused with a triazole ring have been extensively studied. 4 -9 In particular, various substituted 7H-1,2,4-triazolo- [3,4-b] [1,3,4] thiadiazines have been shown to possess diverse pharmacological properties, such as antimicrobial, bactericidal, anti-inflammatory, antiviral, antihypertensive, antifungal, antihelminthic, and analgesic effects. 10 -13 Prompted by the biological properties of 1,2,4-triazole derivatives and 1,3,4-thiadiazines, and in continuation of our studies on Nbridged heterocycles, 14 -15 we report here the synthesis and spectral characterization of some 7H-1,2,4-triazolo [3,4-b] [1,3,4] thiadiazine derivatives (Scheme 1), of which compounds 1a, 1b, 1d, 1e, 1f, 1o, and 1q were known.…”