ChemInform Abstract: Synthesis of N‐Alkyl‐2‐aryl‐5H‐imidazo[1,2‐b]pyrazol‐3‐amines by a Three‐Component Condensation Reaction.

Abstract

Synthesis of N-Alkyl-2-aryl-5H-imidazo[1,2-b]pyrazol-3-amines by a Three-Component Condensation Reaction. -Reaction conditions are optimized for the condensation process. Compared to previous methods, good yields of the title compounds are obtained in short reaction times. -(RAHMATI*, A.; KOUZEHRASH, M. A.; Synthesis 2011, 18, 2913-2920, http://dx.doi.org/10.1055/s-0030-1260154 ; Dep. Chem., Isfahan Univ., Isfahan, Iran; Eng.) -Mais 04-103

Nitrilium ions – synthesis and applications

“…81 Also pyrazole amidines have been shown to react in a 3-component reaction with benzaldehydes and isocyanides to give 3-aminoimidazoles 92 (Scheme 17b). 82 Asymmetric pyrazole tetrazole derivatives have been employed to synthesize heterocycles 93 (Scheme 17c). 83 The intramolecular nucleophile can also be another amine group, as was shown for the reaction of 2,3-diaminomaleonitrile with ketones and isocyanides to afford heterocycle 94 (Scheme 17d); 84 the reaction of ethylenediamine 85 with aldehydes and isocyanides yields similar results.…”