ChemInform Abstract: Synthesis of Medium and Large Rings. Part 27. Chromatographic Separation of the Enantiomeric 3,6‐Heptanophthalides. A Contribution to the Problem of the Absolute Configuration of (n)Paracyclophanecarboxylic Acids.

Abstract

080ChemInform Abstract The partial chromatographic resolution of the racemic title compound (I) is achieved with 40% e.e. on triacetylcellulose with ethanol using a recycling technique. Comparison of the CD spectra of (I) with those of (II) leads to the determination of the absolute configuration (P) for both compounds. This assignment is of interest in view of earlier configurational assignments for (n)paracyclophanecarboxylic acids.