ChemInform Abstract: Synthesis of Medium‐ and Large‐Ring Compounds Initiated by Photochemical Decarboxylation of ω‐Phthalimidoalkanoates.

Abstract

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Synthesis and Modifications of Amino Acids and Peptides via Diradicals

“…Under these special conditions no simple decarboxylation occurs if the carboxyl group is in the &position (or in more remote positions with respect to the excited carbonyl group) but the resulting diradicals preferably cyclize. In this way both small-sized rings such as pyrrolizidine 39 [23] as well as macrocycles such as 42 and 44 may be obtained [24]. The latter results are particularly remarkable because there is obviously no dependence of the cyclization yield on the ring size.…”