ChemInform Abstract: Synthesis of Isoquino[1,2‐a][2]benzazepines and Biochemical Testing of Isomeric Homoberbines and Related Papaverine‐Derivatives for the Inhibition of Phosphodiesterases.

Abstract

Synthesis of Isoquino[1,2-a][2]benzazepines and BiochemicalTesting of Isomeric Homoberbines and Related Papaverine-Derivatives for the Inhibition of Phosphodiesterases. -The synthesis of hitherto not accessible isoquino[1,2-a]benzazepines (V) (6 examples) starting fromhydroxyesters (II) or corresponding benzanellated seven-membered ring lactones is given. Testing of these compounds for inhibition of phosphodiesterases shows that the sterical position of the benzene rings is important. -(MEISE, W.; ONUSSEIT, O.; CLEMENS, M.; Pharmazie 54 (1999) 9, 658-666; Pharm. Inst.,