ChemInform Abstract: SYNTHESIS OF HETEROCYCLES USING 4‐OXO‐4,5,6,7‐TETRAHYDROINDOLES AS BIODYNAMIC MOLECULES

Abstract

Die aus den Tetrahydroindolonen (I) erhältlichen Derivate (III) werden nach den angegebenen Verfahren in die Verbindungen (V) bzw. (VII) übergeführt.

Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents

“…Singh et al 230 and later Agarwal et al 231 synthesized various substituted indoles, but none of the compounds showed antiamoebic activity in axenic culture below the concentration of 62 µg/mL; at lower doses, all the compounds were found to be inactive. 2,6-Disubstituted-1(3)H-imidazo[4,5-c]carbazoles have been prepared, 232 and all the compounds showed in vitro antiamoebic activity only above 31 µg/mL.…”

An expedient general synthesis of pyrrolo[3,2-e]indazoles: domino Sonogashira/Cacchi coupling-heteroannulation reactions

“…The extant literature on the synthesis and bioactivity of pyrroloindazoles revealed that eight isomeric classes of pyrroloindazoles have so far been synthesised. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Of these, only the [2,3-g]-isomers [18][19][20][21][22][23][24][25][26][27] and the [3,2-e]-isomers 22,24,25 display various biological activities. Thus, the [2,3-g]-isomers 1-4 and the [3,2-e]-pyrroloindazole 5 were bioactive.…”

“…Among these two classes of pyrroloindazoles, only the [2,3-g]-types have already been subjected to rather thorough synthetic investigations. [18][19][20][21][22][23][24][25][26][27] But the [3,2-e]-types were synthesized only twice, neither of which was a general route.…”