ChemInform Abstract: Synthesis of Heterocycles. Part 6. Synthesis and Antimicrobial Activity of Some 4‐Amino‐5‐aryl‐1,2,4‐triazole‐3‐thiones and Their Derivatives.

Abstract

The aroyldithiocarbazates (I) are cyclized with hydrazine to form the 4‐aminotriazole‐3‐thiones (II) which are either acylated to give (IV) or alkylated, producing (V) or (VIII).

Syntheses, Characterization and biological Activity of a new ligand [N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)acetamide with some transition metal complexes

“…The resulting mixture was heated under reflux for (6 hours).The resultant mixture was concentrated , and carefully acidified with hydrochloric acid HCl(10%) to give pale yellow precipitate. The crude product was filtered and washed with cold water, recrystallized from ethanol to give the desired product5-Amino-1,3,4thiadiazole-2-thiol (A1) as White needles (7,8), yield (81%),m.p (9).233-235C.A mixture(A1) (0.02mol, 2gm) and Ethyl acetate (0.02mol, 2ml) dissolved in ethanol (50ml) was refluxed on a water bath for(3) hrs, .The resultant mixture[ligand] was concentrated and the Yellow solid which separated was filtered and recrystallised from ethanol. Yield: (86 %), m. p.…”

Syntheses, Characterization and biological Activity of a new ligand [N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)acetamide with some transition metal complexes

“…The resulting mixture was heated under reflux for (6 hours).The resultant mixture was concentrated , and carefully acidified with hydrochloric acid HCl(10%) to give pale yellow precipitate. The crude product was filtered and washed with cold water, recrystallized from ethanol to give the desired product5-Amino-1,3,4thiadiazole-2-thiol (A1) as White needles (7,8), yield (81%),m.p (9).233-235C.A mixture(A1) (0.02mol, 2gm) and Ethyl acetate (0.02mol, 2ml) dissolved in ethanol (50ml) was refluxed on a water bath for(3) hrs, .The resultant mixture[ligand] was concentrated and the Yellow solid which separated was filtered and recrystallised from ethanol. Yield: (86 %), m. p.…”

Synthesis of new heterocyclic compounds having 1,2,3‐triazole and isoxazole rings in a single molecule

“…Isoxazole derivatives form a part of many drugs used for antidepressant therapy and the treatment of osteoarthritis or rheumatoid arthritis [7,8]. On the other hand, 1,3,4-oxadiazoline-5-thiones, 1,2,4-triazolo [3,4-b]-1,3,4-thiadiazines and 1,2,4-triazolo [3,4-b]1,3,4-thiadiazoles have anticancer, antibacterial , antiseptic, anthelmintic and antimicrobial physiological activities [9][10][11][12]. Thus, it seemed of interest to combine various heterocyclic rings into a single molecule with the hope of finding activities and improving the function of some drugs.…”