ChemInform Abstract: Synthesis of Heterobicyclic Nitrogen Systems Bearing the 1,2,4‐Triazine Moiety as Anti‐HIV and Anticancer Drugs. Part 1.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis and anticancer activity of some new pyridine derivatives

“…In addition, triazolopyridines are also interesting compounds due to their pronounced biological activity, as they can be used as antidepressants [11][12][13]. Various pyridine derivatives are well known to possess an array of physiological activities, such as anticancer, muscle relaxant, hypnotic, antiinflammatory, diuretic, and antihypertensive activities [14][15][16][17]. Imidazole derivatives are part of anticancer drugs like mercaptopurine.…”

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

“…Significant activity towards leukemia, ovarian cancer and anti-HIV were observed in vitro for some 3,5,6-trisubstituted-1,2,4-triazines [203][204][205][206][207][208]. 1,2,4-Triazine-N-oxide derivatives have been studied as potential hypoxic cytoxins [209][210][211].…”

Analogs of biologically active compounds IX. Synthesis of several new uracil and pteridine 6-aza-analogs based on cyclization of arylhydrazones derived from mesoxalic acid

“…Many 1,2,4-triazine derivatives are well known to possess biological activities. 2,3 Over the last two decades asymmetric triazines have been screened in vitro supporting their anticancer, [4][5][6] anti-HIV [4][5][6] and tuberculostatic activities. 7 Pyrimido [1,2,4]triazines show interesting biological activities, such as the antibiotics toxoflavine, reumycine, fervenuline and methylfervenuline all possessing a pyrimido [5,4-e][1,2,4]triazine (7-azapteridine) system.…”