Abstract:Synthesis of Dicationic Diarylpyridines as Nucleic-Acid BindingAgents.-The title compounds, e.g. (VII) and (XIII), are tested against topoisomerase II from Giardia lamblia and Pneumonocystis carinii. Only compound (VII) is active at micromolar concentrations. (VIII) also shows significant anti-HIV activity. -(KUMAR, A.; RHODES, R. A.; SPYCHALA, J.; WILSON, W. D.; BOYKIN, D. W.; TIDWELL, R. R.; DYKSTRA, C. C.; HALL, J. E.; JONES, S. K.; SCHINAZI, R. F.; Eur.
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