ChemInform Abstract: Synthesis of Bicyclic N‐Methylpyrazoline and Pyrazole Derivatives from α,β‐Unsaturated Ketones and N,N‐Dimethylhydrazine: An Illustration of Reductive Cyclization.

Abstract

Reductive Cyclization. -The reaction of N,N-dimethylhydrazine with arylideneketones gives rise to the formation of bicyclic pyrazoline and N-methylpyrazole derivatives instead of hydrazones or Michael addition products. These reactions demonstrate an interesting phenomenon of ring cyclization via reductive N-demethylation. -(PANDA, A. K.; DAS, U.; QUAIL, J. W.; DIMMOCK*, J. R.; J. Heterocycl. Chem. 51 (2014) 1, 219-223, http://dx.doi.org/10.1002/jhet.1570 ; Coll. Pharm. Nutr., Univ. Saskatchewan, Saskatoon, Sask. S7N 5C9, Can.; Eng.) -H. Hoennerscheid 28-109