ChemInform Abstract: Synthesis of Azepino[4,5‐b]indolones by an Intramolecular Cyclization of Unsaturated Tryptamides.

Abstract

Synthesis of Azepino[4,5-b]indolones by an Intramolecular Cyclization of UnsaturatedTryptamides. -The seven step synthesis of the starting materials is described. Product (IId) is further transformed into the tetracyclic ABCD core structure of tronocarpine (XVII), and compound (IIb) is further converted into the tetracyclic scaffold of ibogamine (XVIII) and catharanthine (XIX). -(NIDHIRY, J.; PRASAD*, K. R.; Synlett 25 (2014) 18, 2585-2590, http://dx.