ChemInform Abstract: SYNTHESIS OF ASYMMETRICALLY DISUBSTITUTED UREA AND THIOUREA DERIVATIVES. PART 1

Abstract

95%iger Ausbeute die Hanrstoff‐ bzw. Thioharnstoffderivate (III) erhalten.

Synthesis of Phenazone Derivatives

“…1-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-phenyl-thiourea (2a): [15][16][17][18][19][20][21] 1,3-Disubstituted perhydro-pyrimidine-2-ones (4d,e): General procedure: A mixture of compound 2d or 2e (10 mmol) and 1,3dichloropropane (10 mmol) in DMF (20 ml) was boiled under reflux for 4 h. After cooling to 25 °C, the reaction mixture was poured on ice. The precipitated solid was filtered off.…”

Amidetriazole: A Versatile Building Block for Construction of Oxyanion Anion Receptors

“…The synthesis of urea derivatives involves the toxic reagents isocyanate or phosgene. Unsymmetrical urea derivatives are relatively difficult to obtain 4. As a result, a building block with slight structural variation but similar functionality to the urea moiety is desirable for construction of artificial receptors for tetrahedral anions.…”