ChemInform Abstract: Synthesis of all‐E‐ and 9Z‐Heteroaryl‐retinoic Acid Applying Palladium Catalyzed Coupling Reaction of (Arylvinyl)tributyl Stannane with Vinyl Triflate.

Abstract

Synthesis of all-E-and 9Z-Heteroaryl-retinoic Acid Applying Palladium Catalyzed Coupling Reaction of (Arylvinyl)tributyl Stannane with Vinyl Triflate. -Stille-type cross-coupling of stereodefined (E)-and (Z)-vinyl triflates (II) and (VII) with vinylstannanes (I) produces stereopure (E)-and (Z)-olefins in good yields. These products [cf. (III)] are readily transformed to hetaryl analogues (VI) of retinoic acid. -(WADA,