ChemInform Abstract: Synthesis of a New Chiral Phosphine Ligand.

Abstract

ChemInform Abstract The new chiral diphosphine (S)-(IX) is synthesized from mucochloric acid (I) via the dichloro-Ni(II) complex (VIIa) as shown in the scheme. The structure of the diiodo complex (VIIb) (space group P212121, Z=4) is determined by X-ray analysis.

Antimicrobial Effects of Sulfonyl Derivative of 2(5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and -Susceptible Staphylococcus aureus

“…The 2(5 H )-furanone derivative F105 (4) was synthesized in three steps from commercially available mucochloric acid 1 (see Figure 1 ). In the first stage, a mixture of diastereomers 2a + 2b was obtained in the reaction of mucochloric acid 1 with l -menthol in the presence of catalytic amounts of concentrated sulfuric acid as described previously ( Fenske and Merzweiler, 1989 ). The pure stereoisomer 2a with S -configuration of the carbon atom C 5 of the γ-lactone ring was isolated in 52% yield after two recrystallizations from hexane ( Figure 1 ).…”

“…Among various compounds exhibiting antimicrobial and anti-biofilm activities, the derivates of 2(5 H )-furanone have been intensively studied in last two decades. In the nature, furanones are known to exhibit many different functions, such as intra- and inter-species signaling and communication, attractant molecules and pheromones, antimicrobials, and anti-carcinogens ( Fenske and Merzweiler, 1989 ; Donlan and Costerton, 2002 ; Bremer et al, 2011 ). Several studies have reported the ability of synthetic furanones to inhibit biofilm formation of various bacteria ( Ren et al, 2001 ; Hentzer et al, 2002 ; Lonn-Stensrud et al, 2009 ; Fedorova et al, 2013 ).…”