ChemInform Abstract: Synthesis of 6‐Substituted 2‐Phenyloxazolo(4,5‐b)pyridines.

Abstract

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Rhodium-Catalyzed 1,4-Addition of Arylboronic Acids to 3-Benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Derivatives

“…[9] Compounds 1a-e have been obtained in a mixture of E and Z isomers with moderate to good yields. The NMR studies and comparisons with the literature have shown that the E isomer is the major one.…”

“…We began our studies by synthesizing 3-benzylidene-1 H -pyrrolo[2,3- b ]pyridin-2(3 H )-ones by condensation between 7-azaoxindoles with various aldehydes (Table ) …”

Robust and Scalable Approach to 1,3‐Disubstituted Pyridylcyclobutanes

“…[2 + 2] cycloaddition with ketenes, as well as double alkylation of pyridyl‐substituted active methylene compounds with 1,3‐dibromo‐2,2‐dimethoxypropane ( 16 ) (Scheme ). It should be noted that neither approach has been used for the preparation of functionalized 1,3‐disubstituted pyridylcyclobutanes to date, although the latter strategy was applied for the synthesis of cyclobutylpyridines lacking other substituents at the cyclobutane ring …”