ChemInform Abstract: Synthesis of 4‐Oxopyrrolo(1,2‐a)pyrimidine‐3‐carboxylic Acid Derivatives as Potential Antimicrobial Agents.

Abstract

The synthesis of the title compounds, e.g. (IV), is achieved by reaction of 2‐aminopyrroles, e.g. (I), with the ethoxymethylenemalonate (II) followed by cyclization of the aminomethylene derivative (III).

The Chemistry of α-Haloketones and Their Utility in Heterocyclic Synthesis

“…A general methodology for the synthesis of a wide variety of substituted 3-aminopyrroles 36 via the reaction of N -aryl and N -alkylaminomethylenecyanoacetic acid derivatives 34 with α-halogenated carbonyl compounds in the presence of potassium carbonate or sodium ethoxide has been reported ( Scheme 10 ) [ 114 , 115 , 116 , 117 , 118 , 119 , 120 ].…”

“…Reaction of 2-aminoazoles 169 with phenacyl bromides in the presence of dicyclohexylmethyl-amine gave the corresponding mono-alkylated products 170 . The latter upon treatment with a strong base afforded fused pyrimidine deri-vatives 172 ( Scheme 49 ) [ 367 , 368 , 369 , 370 ].…”