ChemInform Abstract: Synthesis of 4′‐Ester Analogues of Resveratrol and Their Evaluation in Malignant Melanoma and Pancreatic Cell Lines.

Abstract

Melanoma and Pancreatic Cell Lines. -Ester analogues (IV) of resveratrol are synthesized from resorcylic acid using a decarbonylative Heck coupling as key step. (IV) are significantly more cytotoxic than resveratrol against DM443 and DM738 cells. -(WONG, Y.; OSMOND, G.; BREWER, K. I.; TYLER, D. S.; ANDRUS*, M. B.; Bioorg. Med.