ChemInform Abstract: Synthesis of 3β‐Aryl‐8‐azabicyclo(3.2.1)octanes with High Binding Affinities and Selectivities for the Serotonin Transporter Site.
Abstract:Synthesis of 3β-Aryl-8-azabicyclo(3.2.1)octanes with High Binding Affinities and Selectivities for the Serotonin Transporter Site. -The tropane analogues (III) and (IV) of cocaine are synthesized and tested in binding to dopamine, serotonin and norepinephrine transporters. The most potent and selective compound is (IIId). -(DAVIES, H. M. L.; KUHN, L. A.; THORNLEY, C.; MATASI, J. J.; SEXTON, T.; CHILDERS, S. R.; J. Med.
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