ChemInform Abstract: Synthesis of 3′‐Cyano‐3′‐deoxy‐β‐D‐arabino‐nucleosides.

Abstract

The compounds (III) mentioned in the title are prepared by regioselective ring cleavage of the lyxo‐epoxides (I) with cyanodiethylaluminum (II).

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

“…17 The same author used hydrazoic acid as 1,3-dipole and a carbodiimide as dipolarophile, generated from AZT, for the elaboration of compound 6, which also exhibited moderate activity against HIV-1. 18 The series of products 7 were prepared and tested as antiviral HIV agents, the most active being R 1 = Bu t (Me) 2 Si-, R 2 , R 4 = H, R 3 = CONMe 2 . 19 Phosphasugar Fig.…”

“…17 The same author used hydrazoic acid as 1,3-dipole and a carbodiimide as dipolarophile, generated from AZT, for the elaboration of compound 6, which also exhibited 75 moderate activity against HIV-1. 18 The series of products 7…”