Abstract:Synthesis of 2-Aryl-3-(2-cyanoethyl)aziridines and Their Chemical and Enzymatic Hydrolysis Towards-Lactams and -Lactones. -The title compounds (IV) are transformed into variable mixtures of 4-[aryl(alkylamino)methyl]butyrolactones and 5-[aryl(hydroxy)methyl]pyrrolidin-2-ones by KOH-mediated hydrolysis of the cyano group, followed by ring expansion. The enzymatic hydrolysis of (IV) using nitrilase is performed as well and found to be a selective route to the functionalized -lactams (VI). -(MOLLET, K.; DECUYP… Show more
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