ChemInform Abstract: Synthesis of 2,5,6‐Trisubstituted Benzimidazoles by Heck and Subsequent 6π‐Electrocyclization—Dehydrogenation Reactions of 2,4,5‐Tribromo‐N‐methylimidazole and 2‐Aryl‐4,5‐dibromo‐N‐methylimidazole.

Abstract

Heck reaction of tribromo imidazoles (I) and dibromo analogues (VI), obtained by arylation of (I), with vinyl compounds produces dialkenyl imidazoles which undergo 6π‐electrocyclization—dehydration to give the title benzimidazoles.