ChemInform Abstract: Synthesis of 1,4‐Dihydropyridine Derivatives Containing Hydroxy‐, Alkoxy‐ or Dimethylaminophenyl Substituents at the 4‐Position, Their Antioxidant Activity and Binding to Phospholipid Membranes.

Abstract

Synthesis of 1,4-Dihydropyridine Derivatives Containing Hydroxy-, Alkoxy-or Dimethylaminophenyl Substituents at the 4-Position, Their Antioxidant Activity and Binding to Phospholipid Membranes. -A series of dihydropyridines of type (III) (21 examples) is synthesized by the Hantzsch method. Some 3,5-diamides and 4-(3',4'-dihydroxyphenyl) derivatives of (III) display antioxidant activity and an affinity to model phospholipid membranes. -(PLOTNIETSE, M.; TIRZITIS, G.; ULDRIKIS, YA.; KORONOVA, ZH.; TIRZITE, D.; MAKAROVA, N.; DUBURS, G.; Khim.