ChemInform Abstract: Synthesis, Molecular Modelling and Biological Evaluation of 4‐Amino‐2(1H)‐quinazolinone and 2,4(1H,3H)‐Quinazolidone Derivatives as Antitumor Agents.

Abstract

Synthesis, Molecular Modelling and Biological Evaluation of 4-Amino-2(1H)-quinazolinone and 2,4(1H,3H)-Quinazolidone Derivatives as AntitumorAgents. -Various 6-benzoyl-, 6-arylthio-, 6-arylsulfonyl-4-amino-2(1H)-quinazolinones, and -2,4(1H,3H)-quinazolinediones are synthesized and screened for their in vitro cytotoxicity against the NCI-60 cancer cell lines. Some of them display moderate antitumor activities. -(RICHTER, S.; GIOFFREDA*, B.; Arch. Pharm. (Weinheim, Ger.) 344 (2011) 12, 810-820, http://dx.doi.org/10.1002/ardp.201000312 ; Inst. Pharm. Chem., Heinrich-Heine-Univ., D-40225 Duesseldorf, Germany; Eng.) -H. Toeppel