ChemInform Abstract: Synthesis, in vitro Antibacterial and Antifungal Evaluations of New α‐Hydroxyphosphonate and New α‐Acetoxyphosphonate Derivatives of Tetrazolo[1,5‐a]quinoline.

Kategaonkar, Amol H.; Pokalwar, Rajkumar U.; Sonar, Swapnil S.; Gawali, Vaibhav U.; Shingate, Bapurao B.; Shingare, Murlidhar S.

doi:10.1002/chin.201028182

Cited by 3 publications

(3 citation statements)

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“…The differences in size, shape, and basicity of the carboxylate and phosphonate groups might reflect in differences in the enzyme-substrate interactions. The inhibitory action of aminophosphonates enable their use in design of enzyme regulators and application as antibacterial, antimicrobial, neuroactive, antitumor, antiviral, fungicidal, and herbicidal agents [1,5,6]. The derivatives containing pyridine and quinoline heterocyclic rings are also very attractive metalcomplexing agents that might form biologically important metal complexes.…”

Section: Introductionmentioning

confidence: 99%

Electrospray Ionization Mass Spectrometry of Palladium(II) Quinolinylaminophosphonate Complexes

Juribašić

Bellotto

Traldi

et al. 2011

J. Am. Soc. Mass Spectrom.

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The mass spectrometric behavior of palladium(II) halide complexes of three types of quinolinylaminophosphonates, diethyl and dibutyl esters of [α-anilino-(quinolin-2-yl)methyl] phosphonic (L1, L2), [α-anilino-(quinolin-3-yl) + is observed in the mass spectra of all the complexes, and its abundance as well as the fragmentation pathway depend on the type of the complex. In the cis complexes (1-4) the initial decomposition goes under two fragmentation routes: those in which the sodium molecular adduct sequentially loses halides HX/NaX and those in which this loss is in the competition with the loss of dialkyl phosphite. The predominant pathways for decomposition of trans dihalide (5-8) and tetrahalide (9-12) complexes include three competitive reactions; the loss of halides, dialkyl phosphites and the intact phosphonate ligand molecule and its fragments formed by ester dissociation or complete loss of the phosphonate ester moiety. A series of acetonitrile adducts and cluster ions derived from dimolecular clusters [2M + Na] + were also detected. The most important fragmentation patterns are rationalized and supported by the MS n studies.

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Section: Introductionmentioning

confidence: 99%

Electrospray Ionization Mass Spectrometry of Palladium(II) Quinolinylaminophosphonate Complexes

Juribašić

Bellotto

Traldi

et al. 2011

J. Am. Soc. Mass Spectrom.

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“…O n e o f t h e i m p o r t a n t c l a s s e s o f organophosphorus there is α-hydroxyphosphonates which have attracted an immense attention due to their biological activities such as enzymes inhibitors 1 , anti-bacterial and anti-fungal 2,3 , anticancer 4,5 , and anti-HIV activities 6 . Adding to that best-known example of phosphonates activity is their potent insecticidal activities 7 .…”

Section: Introductionmentioning

confidence: 99%

Mineral Oil Shale Part Based-Support as Heterogeneous Catalyst for Organophosphorus Synthesis Assisted by Ultrasounds

et al. 2022

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A new heterogeneous catalyst has been developed based on moroccan oil shale raw matter. This new support was used in the α-hydroxyphosphonates synthesis by Pudovik pathway using dialkylphosphites and carbonyls compounds. The transformation was performed by using oil shale-based catalyst under room temperature and by ultrasound-assisted synthetic approach. Both approaches have been found to be efficient in this organophosphorus synthesis. The reaction was carried out with a high yield in dry media, the catalyst is separated easily and reused several times without losing its activity.

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“…Tetrazoles are bioisosteres of the carboxyl group and act as ligand-binding functionality for CYP450-derived oxidative metabolic processes (Herr, 2002). The tetrazole group possesses wide range of biological activities such as cytotoxic (Bekhit et al, 2004a), anti-inflammatory (Bekhit et al, 2004b), antimicrobial (Kategaonkar et al, 2010) and even recognized as inhibitor of hepatitis C virus (HCV) (Thota et al, 2008). This prompted us constructing novel compounds containing fused quinoline and tetrazole ring systems in the same matrix to serve as a new pharmacophore.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, molecular docking and biological evaluation of some novel tetrazolo[1,5-a]quinoline incorporated pyrazoline and isoxazoline derivatives

Nikam

Mahajan

Damale³

et al. 2015

Med Chem Res

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A series of new pyrazolines (4a-4g) and isoxazolines (5a-5g) have been synthesized in good-to-excellent yield from the corresponding chalcones (3a-3g) under ultrasound irradiation. The newly synthesized compounds were characterized and screened for their in vitro antimicrobial activity against different bacterial and fungal strains by standard agar dilution method and in vitro antioxidant activity by using DPPH method. Some of the synthesized compounds displayed significant antimicrobial and antioxidant activity. Docking study of the synthesized compounds has been performed, and results showed good binding mode in the active site of fungal enzyme P450 cytochrome lanosterol 14 a-demethylase. ADMET properties of synthesized compounds showed good drug-like properties.

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ChemInform Abstract: Synthesis, in vitro Antibacterial and Antifungal Evaluations of New α‐Hydroxyphosphonate and New α‐Acetoxyphosphonate Derivatives of Tetrazolo[1,5‐a]quinoline.

Cited by 3 publications

References 1 publication

Electrospray Ionization Mass Spectrometry of Palladium(II) Quinolinylaminophosphonate Complexes

Electrospray Ionization Mass Spectrometry of Palladium(II) Quinolinylaminophosphonate Complexes

Mineral Oil Shale Part Based-Support as Heterogeneous Catalyst for Organophosphorus Synthesis Assisted by Ultrasounds

Synthesis, molecular docking and biological evaluation of some novel tetrazolo[1,5-a]quinoline incorporated pyrazoline and isoxazoline derivatives

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