ChemInform Abstract: Synthesis, Characterization and Antimicrobial Screening of Novel Quinoline‐Thiazole Derivatives (VII).

Utility of N′‐((2‐chloroquinolin‐3‐yl)methylene)‐2‐cyanoacetohydrazide as a Source of Biologically Active Novel Heterocycles

“…Subsequent addition of hydrazine hydrate to the previous mixture afforded the pyrazole derivative 10 . On the other hand, the reaction of compound 1 with equivalent amounts of elemental sulfur and phenyl isothiocyanate with a catalytic amount of triethylamine produced thiazole derivative 11 instead of the aminothiazole derivative 12 as reported . The appearances of an absorption band in the IR spectrum corresponding to CN group as well as the absence of a broad singlet signal for amino group protons in 1 H NMR exclude structure 12 .…”

“…N ′‐((2‐chloroquinolin‐3‐yl) methylene)‐2‐cyanoacetohydrazide 1 was synthesized from 2‐choloroquinoline‐3‐carbaldehyde and cyanoacetohydrazide as described in literature . In this article, we report the behavior of 1 with different electrophilic and nucleophilic reagents such as hydrazine derivatives.…”

“…It was synthesized by refluxing a mixture of 2‐chloroquinoline‐3‐carbaldehyde (1.92 g, 0.01 mol) and 2‐cyanoacetohydrazide (0.99 g, 0.01 mol) in absolute ethanol for 3 h and cooled to room temperature, mp 175 (literature ; mp 174). To a solution of ( 1 ) (0.82 g, 3 mmol) in dioxane (30 mL), hydrazine hydrate (0.15 mL, 3 mmol), phenylhydrazine (0.29 mL, 3 mmol) and/or 2‐cyanoacetohydrazide (0.30 g, 3 mmol) was added.…”

Landscaping of Quinoline based Heterocycles as Potential Antimicrobial Agents: A Mini Review

“…A series of quinoline clubbed thiazole motifs were synthesized and subjected to antimicrobial evaluation [16,17]. Hybrid structure is depicted in Figure 1.…”