ChemInform Abstract: Synthesis, Characterization and Biological Activity of Some New 1,3,4‐Oxadiazole Bearing 2‐Fluoro‐4‐methoxy Phenyl Moiety.

Chandrakantha, B.; Shetty, Prakash; Nambiyar, Vijesh; Isloor, Nishitha; Isloor, Arun M.

doi:10.1002/chin.201027126

Cited by 6 publications

(5 citation statements)

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“…a-Common Conventional Method (from the corresponding ester): It is the known traditional method for the synthesis of 2nz in which the corresponding ester (mainly, the ethyl ester or 1nz) is hydrazinolyzed using NH 2 NH 2 .H 2 O (hydrazine hydrate) in the presence of EtOH as the refluxing solvent for the reactants (for 6 h in this current research). Generally, many of the references that reported this method in the literature mentioned the use of the ethyl ester for this reaction [22,[31][32][33][34][35][36][37][38], some others mentioned the use of the propyl ester [39][40][41][42][43][44][45][46], while few others mentioned the use of the methyl ester [33,[47][48][49][50].…”

Section: Synthesis Of Galloyl Hydrazide (2nz)mentioning

confidence: 99%

“…Compounds 3n-z were synthesized by using the oxidative cyclodehydration reaction of the hydrazide 2nz with various starting carboxylic acids (S.C.A.) in POCl 3 (phosphorus oxychloride) as the strong dehydrating agent, which is either refluxing POCl 3 (conventional method) or adsorbed POCl 3 (MW-assisted method) [22,31,32,34,39,47,50,53,54]. Table 3 shows the heating time (in h and min "minutes", respectively) and power (in W "watts") needed by the conventional method (method A) and MW method (method B).…”

Section: Synthesis Of 5-substituted-2-(345-trihydroxyphenyl)-134-oxadiazoles (3n-z)mentioning

confidence: 99%

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Design, Synthesis, and Biological Evaluation of Novel 5-Substituted-2-(3,4,5-trihydroxyphenyl)-1,3,4-oxadiazoles as Potent Antioxidants

Rabie¹,

Tantawy²,

Badr³

2016

ajoc

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A novel series of 5-(5-substituted-1,3,4-oxadiazol-2-yl)benzene-1,2,3-triols (3n-z) was designed, synthesized, and evaluated for its potential antioxidant activities. Structural modifications at position 5 of the 1,3,4-oxadiazole scaffold (linked to a fixed antioxidant 3,4,5-trihydroxyphenyl moiety at position 2 of the ring) was expected to give new 1,3,4-oxadiazole derivatives with a wide spectrum of biological antioxidant activities. Undoubted elucidation and full confirmation of the chemical structures of all the newly synthesized compounds were accomplished using the spectroscopical and elemental analyses. The pharmacological screening for evaluation of the antioxidant activity of these new thirteen target 5-substituted-2-(3,4,5-trihydroxyphenyl)-1,3,4-oxadiazoles (3n-z) was done by using two of the most common in vitro antioxidant assays. The results of both assays showed that compounds 3w,s,u (the fumaric, malonic, and citric acids-derived 1,3,4-oxadiazoles, respectively) surprisingly exhibited very high and significant antioxidant activities, and they could be very promising lead and parent compounds for the design and synthesis of new antioxidant agents by further in vivo biological evaluations, structural modifications, and computational studies.

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Section: Synthesis Of Galloyl Hydrazide (2nz)mentioning

confidence: 99%

Section: Synthesis Of 5-substituted-2-(345-trihydroxyphenyl)-134-oxadiazoles (3n-z)mentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of Novel 5-Substituted-2-(3,4,5-trihydroxyphenyl)-1,3,4-oxadiazoles as Potent Antioxidants

Rabie¹,

Tantawy²,

Badr³

2016

ajoc

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“…Nitrogen-and oxygen-containing five/six-membered heterocyclic compounds are of enormous significance in the field of medicinal chemistry (Chandrakantha et al, 2010). Oxadiazoles play a very vital role in the preparation of various biologically active drugs with anti-inflammatory (Andersen et al, 1994), anti-cancer (Showell et al, 1991), anti-HIV (Watjen et al, 1989, anti-diabetic and anti-microbial (Swain et al, 1991) activities.…”

Section: Commentmentioning

confidence: 99%

Bis[2-(cyclopropyliminomethyl)-5-methoxyphenolato]zinc(II)

Bai¹

2010

Acta Cryst E

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“…1 Due to the increased hydrolytic and metabolic stability of the oxadiazole ring, improved pharmacokinetic properties are often observed, which make this skeleton an important structural moiety for the pharmaceutical industry. 2 Consequently, 1,3,4-oxadiazoles have often been the target of numerous drug discovery programs as anti-inflammatory, analgesic, antibacterial, fungicidal, hyperglycaemic, antimalarial, antidepressant agents, and other activities.…”

Section: Introductionmentioning

confidence: 99%