ChemInform Abstract: Synthesis, Antiulcer and Antidepressive Activity of 4‐(4‐Halophenyl)‐2‐ methyl‐1,2,3,4‐tetrahydroisoquinolines.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of 6,12-Methanodibenzo[c,f]azocines and 4-Aryltetrahydroisoquinolines from Aromatic Aldehydes

“…The desired 2,8-dimethyl-4-(4-tolyl)­tetrahydroisoquinoline 8d was formed in 27% overall yield utilizing 2-methylbenzyl chloride as an alkylating reagent (Scheme ). We also synthesized the patented 4-(4-bromophenyl)­tetrahydroisoquinoline 8e , possessing antidepressant and antiulcer activities, from 4-bromobenzaldehyde in 43% overall yield. Related anisyl derivatives 8f and 8g were obtained in 50 and 62% overall yields correspondingly.…”