ChemInform Abstract: Synthesis and Structure of 5‐Alkyl(aryl)pyrrol‐2‐ones.

Egorova, A. Yu.; Sedavkina, V. A.; Timofeeva, Z. Yu.

doi:10.1002/chin.200214117

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2009

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to providing a series of analogues, a synthesis of pure compounds would minimize the risk of false positives in further assays. A survey of the literature revealed that there have been previous reports of the synthesis of the core 3-alkylidene-4-pyrrolin-2-one scaffold 10. Many of these routes utilize 3-alkylidene-furan-2-ones as starting materials 10a,10d,11.…”

Section: Introductionmentioning

confidence: 99%

Investigation of N-Aryl-3-alkylidenepyrrolinones as Potential Niemann−Pick Type C Disease Therapeutics

et al. 2009

View full text Add to dashboard Cite

A five-step synthesis of an array of N-aryl-3-alkylidenepyrrolinones, which are potential NiemannPick type C (NPC) disease therapeutics, is described. The synthetic route allows for the production of analogues, including photoaffinity and biotinylated derivatives. Compound 1a increased esterification by acyl-coenzyme A:cholesteryl acyltransferase in NPC1 mutant cells. It also decreased LDL uptake and increased cholesterol efflux in both NPC1-deficient and normal cells.

show abstract