ChemInform Abstract: SYNTHESIS AND SOME PROPERTIES OF A NEW VINCAMINE DERIVATIVE

Galzigna, L; Quadro, G.; Saccarello, Maria Luisa; Stradi, Riccardo

doi:10.1002/chin.198129352

Cited by 1 publication

(2 citation statements)

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“…In 1964 Kuehne (18) reported on the synthesis of vincamine and in 1973 Szantay et al, (19) published the stereochemical synthesis of vincamine. On the basis of these results, many vincamine derivates have been synthesized and some of them have proved to be pharmacologically active: vinpocetine (20), epi-21-desethyleburnamonine (21), eburnamonine (22), eburnamine (23), apovincamine (24), MR 411 (25). The most widely studied derivative of vincamine is vinpocetine which has proved to be very effective in the treatment of cerebrovascular disorders.…”

Section: Historymentioning

confidence: 99%

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Pharmacokinetics and metabolism of vincamine and related compounds

Vereczkey

1985

European Journal of Drug Metabolism and Pharmacokinetics

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The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been reviewed. The main route of elimination for vincamine, vinpocetine and methylene-methoxy-apovincaminic acid ester is ester cleavage and conjugation in the case of eburnamine. Vincamine and its derivatives show significant differences in metabolic pathway and their elimination is rapid in the species studied. Emphasis has been placed on the analytical methods used for monitoring these drugs in biological systems.

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Section: Historymentioning

confidence: 99%

“…The protein binding is 60% in human and 70% in rat plasma (91). 25.4 ± 6.26 I/h (86) 0.32 ± 0.11 I/h/kg (82) 0.80 ± 0.16 (10 mg vinpocetine p.o. (85) 3.9 ± 1.6 (I mg/kg vinpocetine in infusion (82) 2 Galzigna et al (25) reported on the vasodilatory effect of the methylenemethoxy-apovincaminic acid ester (Fig.…”

Section: Mr-711mentioning

confidence: 99%